Description

2-Bromo-3-Fluoro-1-Methoxy-4-Nitrobenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. This compound is primarily sought after by R&D chemists and process development scientists for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially those containing fluorinated and nitro-substituted aromatic rings.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of halogen and nitro groups.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations due to the bromo substituent.
• Nucleophilic Aromatic Substitution: The presence of electron-withdrawing nitro and fluoro groups activates the ring for substitution reactions, useful for introducing diverse functionalities.
• Dye and Pigment Intermediate: Employed in the synthesis of complex organic dyes and pigments where halogen and nitro groups modify color and properties.

Basic Information

Product Name	2-Bromo-3-Fluoro-1-Methoxy-4-Nitrobenzene
CAS No.	1805556-17-5
Molecular Formula	C7H5BrFNO3
Molecular Weight	250.02 g/mol
Synonyms	1-Bromo-2-fluoro-3-methoxy-6-nitrobenzene; 2-Bromo-3-fluoroanisole-4-nitro; 3-Fluoro-2-bromo-1-methoxy-4-nitrobenzene; Benzene, 2-bromo-3-fluoro-1-methoxy-4-nitro-; 4-Nitro-2-bromo-3-fluoroanisole; 2-Bromo-3-fluoro-4-nitroanisole
EINECS	Contact for details

Quality Control

Our 2-Bromo-3-Fluoro-1-Methoxy-4-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications and industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.