Description

1,2-Difluoro-3-Methyl-5-Nitrobenzene is a high-purity fluorinated nitroaromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a valuable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring fluorinated aromatic scaffolds to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoro and nitro groups contribute to biological activity and environmental persistence.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and electronic materials.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to introduce fluorinated aniline derivatives into target molecules.
• Dye and Pigment Intermediate: Utilized in the production of specialized dyes and pigments where fluorine substitution alters color fastness and spectral properties.

Basic Information

Product Name	1,2-Difluoro-3-Methyl-5-Nitrobenzene
CAS No.	1805056-06-7
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	3-Methyl-1,2-difluoro-5-nitrobenzene; 2,3-Difluoro-6-nitrotoluene; 1,2-Difluoro-3-methyl-5-nitro-benzene; 5-Nitro-1,2-difluoro-3-methylbenzene; Benzene, 1,2-difluoro-3-methyl-5-nitro-; Toluene, 2,3-difluoro-6-nitro-; Difluoromethylnitrobenzene
EINECS	Contact for details

Quality Control

Our 1,2-Difluoro-3-Methyl-5-Nitrobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical data are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.