Description

1-Chloro-2,5-difluoro-3-nitrobenzene is a high-purity, multi-functional halogenated nitrobenzene derivative, serving as a critical building block in advanced organic synthesis. Its unique substitution pattern makes it an indispensable intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the fluorine and nitro groups enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores in electronic materials for displays and lighting applications.
• Polymer Modification: Employed to introduce halogen and nitro functional groups into polymer backbones, altering thermal and optical properties.
• Dye & Pigment Intermediate: Facilitates the synthesis of specialized, color-fast dyes and pigments for high-performance applications.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions to construct biaryl systems.
• Chemical Research & Development: A versatile reagent for exploring new reaction pathways and synthesizing complex fluorinated aromatic compounds in academic and industrial labs.

Basic Information

Product Name	1-Chloro-2,5-difluoro-3-nitrobenzene
CAS No.	1805029-24-6
Molecular Formula	C6H2ClF2NO2
Molecular Weight	193.54 g/mol
Synonyms	3-Nitro-1-chloro-2,5-difluorobenzene; 2,5-Difluoro-3-nitrochlorobenzene; 1-Chloro-2,5-difluoro-3-nitro-benzene; Benzene, 1-chloro-2,5-difluoro-3-nitro-; 1805029-24-6
EINECS	Contact for details

Quality Control

Every batch of our 1-Chloro-2,5-difluoro-3-nitrobenzene is manufactured and tested under a strict quality management system. We guarantee high chemical purity and consistency, supported by comprehensive analytical documentation. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request to ensure compliance with your specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, open flames, and incompatible materials such as strong reducing agents. For long-term storage, consider maintaining under an inert atmosphere like nitrogen or argon.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.