Description

4-Cyano-2,5-Difluorothioanisole is a high-value fluorinated aromatic building block, essential for the synthesis of advanced pharmaceutical intermediates and agrochemicals. Its molecular structure, featuring both cyano and difluoro substituents on a thioanisole core, makes it a critical precursor for creating complex molecules with tailored biological activity. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorinated motifs into their target compounds.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the difluorothioanisole moiety enhances bioavailability and stability.
• Liquid Crystal Materials: Serves as a building block for advanced liquid crystal compounds used in display technologies.
• Organic Electronic Materials: Employed in the synthesis of organic semiconductors and charge-transport materials for OLEDs and other electronic devices.
• Cross-Coupling Reactions: Acts as a versatile substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new methodologies in fluoroorganic chemistry.

Basic Information

Product Name	4-Cyano-2,5-Difluorothioanisole
CAS No.	1804896-75-0
Molecular Formula	C8H5F2NS
Molecular Weight	185.20 g/mol
Synonyms	2,5-Difluoro-4-(methylthio)benzonitrile; 4-(Methylthio)-2,5-difluorobenzonitrile; 2,5-Difluoro-4-methylthiobenzonitrile; 1-Cyano-2,5-difluoro-4-methylthiobenzene; Benzonitrile, 2,5-difluoro-4-(methylthio)-; 4-Methylsulfanyl-2,5-difluorobenzonitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Cyano-2,5-Difluorothioanisole is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by HPLC), identity confirmation (by NMR and IR), and levels of specific impurities. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.