Description

2,4-Difluoro-5-Iodo-Benzonitrile is a high-value, multi-functional aromatic building block featuring a strategically substituted benzonitrile core. This compound matters for its unique combination of fluorine and iodine substituents, which enables precise structural modifications in advanced synthetic pathways. It is primarily needed by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing novel active ingredients and complex organic molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides where the difluoro-iodo motif confers specific biological activity.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other functional materials requiring halogenated aromatic structures.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Negishi couplings for carbon-carbon bond formation.
• Fluorine Chemistry Studies: An important reagent for investigating the effects of fluorine substitution on molecular properties like lipophilicity, metabolic stability, and binding affinity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and fine chemical companies for bespoke synthesis projects requiring halogenated nitriles.

Basic Information

Product Name	2,4-Difluoro-5-Iodo-Benzonitrile
CAS No.	1803837-32-2
Molecular Formula	C7H2F2IN
Molecular Weight	264.99 g/mol
Synonyms	5-Iodo-2,4-difluorobenzonitrile; 2,4-Difluoro-5-iodobenzonitrile; Benzonitrile, 2,4-difluoro-5-iodo-; 1803837-32-2; 5-Iodo-2,4-difluorobenzene carbonitrile; 2,4-Difluoro-5-iodo-benzonitrile; 2,4-Difluoro-5-iodobenzene-1-carbonitrile
EINECS	Contact for details

Quality Control

Our 2,4-Difluoro-5-Iodo-Benzonitrile is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or opaque to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.