Description

2,6-Difluoro-4-(trifluoromethyl)benzonitrile is a high-value fluorinated aromatic nitrile building block. This compound is essential for introducing multiple fluorine atoms and a versatile nitrile functional group into complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics where fluorine substitution modulates bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the trifluoromethyl and difluoro motifs for enhanced biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs), where its structure contributes to desired electronic and physical properties.
• Polymer & Resin Modifier: Employed to incorporate fluorine into polymer backbones or side chains, improving chemical resistance, thermal stability, and surface properties of high-performance plastics and coatings.
• Chemical Research & Development: A versatile building block in medicinal chemistry and material science R&D for creating compound libraries and exploring novel chemical spaces.

Basic Information

Product Name	2,6-Difluoro-4-(trifluoromethyl)benzonitrile
CAS No.	1803828-56-9
Molecular Formula	C8H2F5N
Molecular Weight	207.10 g/mol
Synonyms	4-Cyano-3,5-difluorobenzotrifluoride; 2,6-Difluoro-α,α,α-trifluoro-p-tolunitrile; 3,5-Difluoro-4-(trifluoromethyl)benzonitrile; 4-(Trifluoromethyl)-2,6-difluorobenzonitrile; Benzene, 2,6-difluoro-4-(trifluoromethyl)cyanide; 2,6-Difluoro-4-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 2,6-Difluoro-4-(trifluoromethyl)benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.