Description

4,5-Dichloro-2-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its value lies in its versatile reactivity, where the nitrile group and halogen substituents serve as key handles for constructing complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated aromatic cores in electronic and display materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations to introduce complex substituents.
• Nitrile Transformation Chemistry: The cyano group can be converted to amides, acids, tetrazoles, and heterocycles, expanding its utility in library synthesis.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel chemical entities.

Basic Information

Product Name	4,5-Dichloro-2-Fluorobenzonitrile
CAS No.	1803807-05-7
Molecular Formula	C7H2Cl2FN
Molecular Weight	190.00 g/mol
Synonyms	2-Fluoro-4,5-dichlorobenzonitrile; 4,5-Dichloro-2-fluorobenzene carbonitrile; 2-Fluoro-4,5-dichlorobenzene-1-carbonitrile; 1-Cyano-2-fluoro-4,5-dichlorobenzene; Benzonitrile, 4,5-dichloro-2-fluoro-; 4,5-Dichloro-2-fluorophenyl cyanide
EINECS	Contact for details

Quality Control

Our 4,5-Dichloro-2-Fluorobenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.