Description

3-(Difluoromethyl)Cyclobutan-1-Ol is a fluorinated cyclobutanol derivative, a versatile and valuable building block in advanced organic synthesis. Its unique structure, featuring a difluoromethyl group on a strained cyclobutane ring, makes it a critical intermediate for introducing fluorine atoms into target molecules, thereby modulating their physicochemical and biological properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides, where the difluoromethyl group can improve compound activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a fluorinated precursor for synthesizing specialty chemicals used in electronic displays and organic light-emitting diodes.
• Fluorine Chemistry Research: An important reagent for academic and industrial research exploring new fluorination methodologies and the properties of fluorinated compounds.
• Polymer Modification: Can be incorporated into polymer backbones to alter material properties such as chemical resistance, thermal stability, and surface energy.

Basic Information

Product Name	3-(Difluoromethyl)Cyclobutan-1-Ol
CAS No.	1785332-95-7
Molecular Formula	C5H8F2O
Molecular Weight	122.11 g/mol
Synonyms	3-(Difluoromethyl)cyclobutan-1-ol; 3-(Difluoromethyl)-1-cyclobutanol; 1-Cyclobutanol, 3-(difluoromethyl)-; Cyclobutan-1-ol, 3-(difluoromethyl)-; 3-(Difluoromethyl)cyclobutanol; 3-Difluoromethylcyclobutanol
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)Cyclobutan-1-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the high standards required for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile nature, ensure containers are securely sealed when not in use. Keep away from heat, sparks, and open flame. Incompatible with strong bases and fluorinating agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.