Description

1-Bromo-2,3-dimethoxy-4-fluorobenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and methoxy substituents, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and pesticides, leveraging its halogenated aromatic core.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating fluorinated and alkoxy-substituted aromatic units essential in electronic materials.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Functional Group Transformation: The methoxy and fluorine groups provide sites for further selective functionalization, enabling diverse chemical pathways.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	1-Bromo-2,3-dimethoxy-4-fluorobenzene
CAS No.	1781433-64-4
Molecular Formula	C8H8BrFO2
Molecular Weight	235.05 g/mol
Synonyms	2-Bromo-4-fluoro-1,2-dimethoxybenzene; 4-Fluoro-2,3-dimethoxybromobenzene; 2,3-Dimethoxy-4-fluorobromobenzene; Benzene, 1-bromo-2,3-dimethoxy-4-fluoro-; 4-Fluoro-2,3-dimethoxy-1-bromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2,3-dimethoxy-4-fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.