Description

Exicorilant CAS NO 1781244-77-6 is a high-purity, non-steroidal selective glucocorticoid receptor modulator (SGRM) of significant interest in pharmaceutical research and development. This compound matters for its targeted mechanism of action, which is being investigated for the treatment of conditions associated with Cushing's syndrome and other metabolic disorders. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced endocrinology research, preclinical studies, and novel therapeutic development.

Application

• Pharmaceutical R&D as a key active pharmaceutical ingredient (API) intermediate for novel glucocorticoid receptor modulators.
• Preclinical Research for studying the effects of selective glucocorticoid receptor modulation in metabolic and endocrine disease models.
• Reference Standard for analytical method development, validation, and quality control in laboratory settings.
• Biochemical Assays to investigate receptor binding affinity, selectivity, and downstream signaling pathways.
• Metabolic Disorder Studies focusing on potential therapeutic applications for Cushing's syndrome and related conditions.

Basic Information

Product Name	Exicorilant
CAS No.	1781244-77-6
Molecular Formula	C24H24F3N3O4S
Molecular Weight	507.53 g/mol
Synonyms	CORT-125281; (R)-CORT125281; (R)-4-(5-((2,4-Difluorophenyl)(hydroxy)methyl)-1-methyl-1H-imidazol-2-yl)-N-ethyl-2,5-dimethyl-N-(pyridin-3-ylmethyl)furan-3-carboxamide; Relacorilant (R-enantiomer); Exicorilant (R-enantiomer); Selective Glucocorticoid Receptor Modulator (SGRM); CORT 125281
EINECS	Contact for details

Quality Control

Our Exicorilant is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (NMR, IR, MS), purity determination by HPLC, and control of specified impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.