Description

2-Chloro-3,4-Difluorophenylacetonitrile is a high-purity, multi-functional chemical intermediate designed for advanced synthesis. This compound is valued for its unique halogenated aromatic structure, which provides a versatile scaffold for constructing complex molecules in pharmaceutical and agrochemical research. It is primarily sought by R&D chemists and process development scientists in the life sciences and specialty chemical sectors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the difluorophenyl moiety for enhanced biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of advanced polymers and liquid crystals, where the chloro and fluoro substituents modify electronic and physical properties.
• Custom Synthesis and Contract Manufacturing: An essential starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-Chloro-3,4-Difluorophenylacetonitrile
CAS No.	1781063-82-8
Molecular Formula	C8H4ClF2N
Molecular Weight	187.57 g/mol
Synonyms	(2-Chloro-3,4-difluorophenyl)acetonitrile; 2-Chloro-3,4-difluorobenzyl cyanide; α-Chloro-3,4-difluorophenylacetonitrile; 2-Chloro-3,4-difluoro-benzeneacetonitrile; 1781063-82-8; Acetonitrile, (2-chloro-3,4-difluorophenyl)-
EINECS	Contact for details

Quality Control

Our 2-Chloro-3,4-Difluorophenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements of our global clientele. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.