Description

2,3-Difluoro-5-Methoxy-4-Methylphenylacetonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both methoxy and difluoro substitutions, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for molecules requiring a difluorinated aromatic core.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorine atoms enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to develop specialty polymers with unique solubility, thermal, and surface properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodology development and the exploration of new chemical spaces in medicinal and materials chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and libraries for client projects.

Basic Information

Product Name	2,3-Difluoro-5-Methoxy-4-Methylphenylacetonitrile
CAS No.	1706461-19-9
Molecular Formula	C₁₀H₉F₂NO
Molecular Weight	197.18 g/mol
Synonyms	2,3-Difluoro-5-methoxy-4-methylbenzyl cyanide; (2,3-Difluoro-5-methoxy-4-methylphenyl)acetonitrile; 4-Methyl-2,3-difluoro-5-methoxyphenylacetonitrile; 2,3-Difluoro-4-methyl-5-methoxyphenylacetonitrile; 1706461-19-9; Acetonitrile, (2,3-difluoro-5-methoxy-4-methylphenyl)-
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-5-Methoxy-4-Methylphenylacetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere such as nitrogen or argon to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.