Description

3,4-Dichloro-5-(Trifluoromethoxy)Benzonitrile is a high-purity, multi-functional aromatic nitrile building block. This compound is valued for its unique combination of halogen and trifluoromethoxy substituents, which impart significant electronic and steric properties for advanced chemical synthesis. It is primarily sought after by R&D and process development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates. Its structural features make it a critical reagent for introducing specific pharmacophores and enhancing molecular lipophilicity.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel drug candidates, particularly in areas targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial labs for method development, catalysis studies, and exploring new reaction pathways involving nitrile and aryl halide functionalities.
• Ligand and Catalyst Design: The nitrile and halogen groups provide anchor points for creating complex ligands used in transition metal catalysis and organocatalysis.

Basic Information

Item	Details
Product Name	3,4-Dichloro-5-(trifluoromethoxy)benzonitrile
CAS No.	1706458-14-1
Molecular Formula	C8H2Cl2F3NO
Molecular Weight	256.01 g/mol
Synonyms	3,4-Dichloro-5-(trifluoromethoxy)benzonitrile; 5-(Trifluoromethoxy)-3,4-dichlorobenzonitrile; 3,4-Dichloro-α,α,α-trifluoro-5-methoxybenzonitrile; Benzonitrile, 3,4-dichloro-5-(trifluoromethoxy)-; 1706458-14-1
EINECS	Contact for details

Quality Control

Every batch of 3,4-Dichloro-5-(Trifluoromethoxy)Benzonitrile is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support compliance in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Maximum Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.