Description

4-Fluoro-3-Methyl-2-(Trifluoromethyl)Phenylacetonitrile is a high-value, multi-fluorinated aromatic nitrile building block essential for advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethyl substituents, is engineered to impart enhanced metabolic stability, lipophilicity, and bioavailability to target molecules. This compound is critically needed by R&D and process development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms improve biological activity and environmental persistence.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated aromatic units.
• Chemical Research & Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and in process chemistry for route scouting and optimization.
• Fluorine Chemistry: Acts as a versatile substrate for further functionalization via reactions such as hydrolysis, reduction, or cyclization to create diverse fluorinated heterocycles.

Basic Information

Product Name	4-Fluoro-3-Methyl-2-(Trifluoromethyl)Phenylacetonitrile
CAS No.	1706446-60-7
Molecular Formula	C10H7F4N
Molecular Weight	217.16 g/mol
Synonyms	2-(4-Fluoro-3-methyl-2-(trifluoromethyl)phenyl)acetonitrile; (4-Fluoro-3-methyl-2-(trifluoromethyl)phenyl)acetonitrile; 4-Fluoro-3-methyl-2-trifluoromethylbenzyl cyanide; α-(4-Fluoro-3-methyl-2-(trifluoromethyl)phenyl)acetonitrile; 2-(4-Fluoro-3-methyl-2-(trifluoromethyl)phenyl)ethanenitrile
EINECS	Contact for details

Quality Control

Every batch of 4-Fluoro-3-Methyl-2-(Trifluoromethyl)Phenylacetonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the rigorous standards required for pharmaceutical and agrochemical applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.