Description

Potassium Trifluoro(3-Fluoro-2-Morpholinopyridin-4-Yl)Borate is a high-value organoboron reagent and synthetic intermediate, distinguished by its unique trifluoroborate salt moiety. This compound is critical for enabling advanced cross-coupling reactions, offering superior stability and handling compared to traditional boronic acids. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the efficient synthesis of complex, fluorinated heterocyclic scaffolds, which are pivotal in developing new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of fluorinated drug candidates, particularly for kinase inhibitors and other targeted therapies.
• Suzuki-Miyaura Cross-Coupling: Serves as a stable, air-tolerant organoboron reagent for palladium-catalyzed carbon-carbon bond formation in complex molecule assembly.
• Agrochemical Research: Used in the development of novel, fluorinated active ingredients for crop protection products.
• Material Science Precursor: Employed in the synthesis of organic electronic materials and ligands for catalysis.
• Chemical Biology Probes: Facilitates the creation of fluorinated probes for studying biological mechanisms and target engagement.
• Process Chemistry & Scale-Up: Valued for its robustness and predictable reactivity in optimizing manufacturing routes for commercial-scale API production.

Basic Information

Product Name	Potassium Trifluoro(3-Fluoro-2-Morpholinopyridin-4-Yl)Borate
CAS No.	1704704-31-3
Molecular Formula	C9H11BF4KN2O
Molecular Weight	280.11 g/mol
Synonyms	Potassium (3-Fluoro-2-morpholin-4-ylpyridin-4-yl)trifluoroborate; 3-Fluoro-2-morpholin-4-ylpyridine-4-boronic acid, trifluoroborate potassium salt; 4-Pyridineboronic acid, 3-fluoro-2-morpholino-, trifluoroborate potassium salt (1:1:1); 1704704-31-3; Potassium (3-fluoro-2-morpholinopyridin-4-yl)trifluoroborate; (3-Fluoro-2-morpholinopyridin-4-yl)trifluoroborate potassium salt
EINECS	Contact for details

Quality Control

Our Potassium Trifluoro(3-Fluoro-2-Morpholinopyridin-4-Yl)Borate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and elemental analysis, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support development and commercial projects requiring compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH limits
Elemental Analysis	Conforms to theoretical values

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.