Description

1-Bromo-5-Chloro-2-Fluoro-3-Nitrobenzene is a high-purity, multi-substituted aromatic building block essential for advanced organic synthesis. Its unique halogen and nitro substitution pattern makes it a critical intermediate for constructing complex molecules in pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists working on active pharmaceutical ingredients (APIs), crop protection agents, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting complex heterocycles.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated benzene core.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions due to the reactive bromo and chloro substituents.
• Nucleophilic Aromatic Substitution: The nitro and fluoro groups activate the ring for selective substitution, useful for creating diverse chemical libraries.
• Chemical Reference Standard: Supplied as a high-purity standard for analytical method development and quality control in chemical manufacturing.

Basic Information

Product Name	1-Bromo-5-Chloro-2-Fluoro-3-Nitrobenzene
CAS No.	1679357-80-2
Molecular Formula	C6H2BrClFNO2
Molecular Weight	269.44 g/mol
Synonyms	5-Chloro-2-fluoro-3-nitro-1-bromobenzene; 3-Bromo-4-chloro-2-fluoro-1-nitrobenzene; 2-Fluoro-3-nitro-1-bromo-5-chlorobenzene; Benzene, 1-bromo-5-chloro-2-fluoro-3-nitro-; 1-Bromo-5-chloro-2-fluoro-3-nitrobenzene; 1679357-80-2; 5-Chloro-2-fluoro-3-nitrobenzyl bromide (precursor-related)
EINECS	Contact for details

Quality Control

Our 1-Bromo-5-Chloro-2-Fluoro-3-Nitrobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. The compound is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.