Description

Cyclizine CAS NO 1672699-03-4 is a piperazine derivative with significant pharmacological activity, primarily recognized for its antiemetic and antihistaminic properties. This compound is a critical active pharmaceutical ingredient (API) and intermediate, valued for its efficacy in managing nausea and vomiting. It is essential for pharmaceutical manufacturers and research institutions developing therapeutic formulations for motion sickness, vertigo, and related conditions. Our supply ensures high purity and consistent quality to meet stringent pharmaceutical development and production standards.

Application

• Pharmaceutical API: Primary use as the active ingredient in antiemetic and antihistamine medications.
• Veterinary Medicine: Formulation of treatments for motion sickness and nausea in animals.
• Clinical Research: Key reference standard and intermediate in pharmacokinetic and pharmacodynamic studies.
• Drug Development: Serving as a core scaffold for synthesizing novel derivatives with enhanced therapeutic profiles.
• Generic Drug Manufacturing: Production of cost-effective generic versions of established antiemetic drugs.
• Biochemical Research: Tool compound for studying histamine H1 receptor antagonism and vestibular system functions.

Basic Information

Product Name	Cyclizine
CAS No.	1672699-03-4
Molecular Formula	C18H22N2
Molecular Weight	266.38 g/mol
Synonyms	1-(Diphenylmethyl)-4-methylpiperazine; Marzine; N-Benzhydryl-N'-methylpiperazine; Valoid; 1-Diphenylmethyl-4-methylpiperazine; Cyclizine Hydrochloride (salt form); N-Methyl-4-(diphenylmethyl)piperazine
EINECS	Contact for details

Quality Control

Our Cyclizine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) documenting purity, identity, and impurity profiles are provided with every shipment. We adhere to relevant ICH guidelines and can support compliance with cGMP, USP, and EP monograph requirements for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.