Description

Benzonitrile, 2-(Difluoromethyl)-3,6-Difluoro- is a highly fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its unique structure, featuring a difluoromethyl group and multiple fluorine atoms on the benzene ring, makes it a valuable precursor for creating complex molecules with tailored electronic and physicochemical properties. This compound is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated heterocycles and bioactive molecules, leveraging fluorine's ability to modulate metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where the difluoromethyl and nitrile groups contribute to enhanced activity and environmental profile.
• Liquid Crystal & OLED Material Research: Serves as a fluorinated core structure for developing advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs).
• Fluorinated Polymer Chemistry: Acts as a monomer or modifier in the synthesis of specialty polymers with improved chemical resistance, thermal stability, and low surface energy.
• Cross-Coupling Reactions: The nitrile and halogenated aryl structure makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to build complex molecular architectures.
• Chemical Biology & Probe Development: Utilized in the design of fluorinated chemical probes and tags for studying biological systems and mechanisms of action.

Basic Information

Product Name	Benzonitrile, 2-(Difluoromethyl)-3,6-Difluoro-
CAS No.	1672663-80-7
Molecular Formula	C8H3F4N
Molecular Weight	189.11 g/mol
Synonyms	2-(Difluoromethyl)-3,6-difluorobenzonitrile; 3,6-Difluoro-2-(difluoromethyl)benzonitrile; 2-(Difluoromethyl)-3,6-difluorobenzene-1-carbonitrile; Benzonitrile, 3,6-difluoro-2-(difluoromethyl)-; 1-Cyano-3,6-difluoro-2-(difluoromethyl)benzene
EINECS	Contact for details

Quality Control

Our Benzonitrile, 2-(Difluoromethyl)-3,6-Difluoro- is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity building blocks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases, reducing agents, and sources of ignition. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.