Description

Gdc-0927 R-Form is a high-purity, enantiomerically pure small molecule compound of significant interest in pharmaceutical research and development. This compound matters as a critical intermediate or reference standard for the synthesis and study of novel therapeutic agents, particularly in oncology. Pharmaceutical companies, biotechnology research firms, and academic laboratories engaged in drug discovery require this material for its role in developing targeted cancer therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced investigational drug candidates.
• Reference Standard: Used for analytical method development, validation, and quality control in API manufacturing.
• Biochemical Research: Serves as a potent and selective tool compound for studying specific biological pathways and target engagement in vitro.
• Preclinical Development: Utilized in pharmacokinetic, pharmacodynamic, and toxicology studies to support IND (Investigational New Drug) applications.
• Process Chemistry: Employed in route scouting and optimization for scalable GMP (Good Manufacturing Practice) production.

Basic Information

Product Name	Gdc-0927 R-Form
CAS No.	1642297-53-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	GDC-0927 (R-enantiomer); (R)-GDC-0927; GDC0927 R-Form; GNE-0927; NVP-GDC0927; ER Degrader 1 (R-form); Estrogen Receptor Degrader (R-enantiomer); (R)-7-(6-(2-Hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-(trifluoromethyl)cyclohexyl)-3,4-dihydro-1H-pyrido[4,3-b]indol-2(5H)-one
EINECS	Contact for details

Quality Control

Our Gdc-0927 R-Form is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Quality is assured through comprehensive analytical testing including chiral HPLC for enantiomeric excess determination and NMR for structural confirmation. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. The product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.