Description

Methyl 4,4-Difluoropyrrolidine-3-Carboxylate Hydrochloride is a high-purity fluorinated pyrrolidine derivative, serving as a critical building block in modern organic synthesis. Its value lies in its unique difluorinated pyrrolidine scaffold, which is instrumental for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients where fluorine substitution is desired.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in protease inhibitors, kinase inhibitors, and other small molecule therapeutics.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the difluoropyrrolidine moiety can enhance biological activity and environmental stability.
• Chemical Biology & Probe Development: Serves as a versatile scaffold for creating molecular probes and tool compounds to study biological pathways and enzyme functions.
• Material Science: Potential precursor for specialty polymers and advanced materials requiring fluorinated heterocyclic components.
• Medicinal Chemistry SAR Studies: Employed in structure-activity relationship (SAR) explorations to investigate the impact of fluorine atoms and the ester group on potency, selectivity, and ADMET profiles.

Basic Information

Item	Detail
Product Name	Methyl 4,4-Difluoropyrrolidine-3-Carboxylate Hydrochloride
CAS No.	1638764-88-1
Molecular Formula	C7H10F2NO2·HCl
Molecular Weight	209.62 g/mol (Free base: 175.16 g/mol)
Synonyms	Methyl 4,4-difluoro-3-pyrrolidinecarboxylate hydrochloride; 4,4-Difluoropyrrolidine-3-carboxylic acid methyl ester hydrochloride; 3-Carbomethoxy-4,4-difluoropyrrolidine HCl; Methyl 4,4-difluoropyrrolidine-3-carboxylate HCl; 4,4-Difluoro-3-methoxycarbonylpyrrolidine hydrochloride
EINECS	Contact for details

Quality Control

Our Methyl 4,4-Difluoropyrrolidine-3-Carboxylate Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Purity (HPLC, Area%)	≥98.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.