Description

3-Bromo-2,5-Difluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block, essential for advanced organic synthesis. This compound matters for its role as a versatile intermediate in creating complex molecules with tailored electronic and steric properties. It is primarily needed by R&D chemists and process development teams in the pharmaceutical and agrochemical industries for constructing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the fluorine and bromine substituents for bioactivity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor for electron-deficient aromatic cores in electronic materials for displays and lighting.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and Buchwald-Hartwig amination reactions to introduce complex substituents.
• Functional Dye Chemistry: Intermediate for the preparation of specialized dyes and pigments with specific light-absorption properties.
• Polymer Modification: Used to incorporate fluorinated aromatic units into high-performance polymers to enhance thermal and chemical resistance.

Basic Information

Product Name	3-Bromo-2,5-Difluorobenzonitrile
CAS No.	1638487-41-8
Molecular Formula	C7H2BrF2N
Molecular Weight	218.00 g/mol
Synonyms	2,5-Difluoro-3-bromobenzonitrile; Benzonitrile, 3-bromo-2,5-difluoro-; 3-Bromo-2,5-difluorobenzene carbonitrile; 3-Bromo-2,5-difluorophenyl cyanide; BDFBN (abbreviation)
EINECS	Contact for details

Quality Control

Our 3-Bromo-2,5-Difluorobenzonitrile is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.