Description

Carebastine is a high-purity pharmaceutical intermediate and active metabolite of the antihistamine ebastine. This compound is critical for research and development in the pharmaceutical sector, particularly for studies related to pharmacokinetics, metabolism, and the development of analytical methods. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in advanced drug development and quality control processes. Carebastine CAS NO 1628046-47-8 offers a reliable reference standard for ensuring the accuracy and consistency of pharmaceutical analyses.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and qualification of ebastine and its metabolites in drug substances and products.
• Metabolite Research: Used in preclinical and clinical studies to investigate the metabolic pathways, bioavailability, and elimination profiles of antihistamine drugs.
• Analytical Method Development: Essential for developing, validating, and calibrating high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS) methods in quality control laboratories.
• Impurity Profiling: Employed to identify and quantify related substances and degradation products in ebastine-based pharmaceutical formulations.
• Bioequivalence Studies: Acts as a key analyte in studies comparing the performance of generic and innovator drug formulations.
• Pharmacological Research: Utilized in vitro and in vivo studies to understand the specific activity and role of the ebastine metabolite.

Basic Information

Item	Detail
Product Name	Carebastine
CAS No.	1628046-47-8
Molecular Formula	C28H39NO3
Molecular Weight	437.62 g/mol
Synonyms	4-(4-Benzyhydryloxy-1-piperidyl)-1-(4-tert-butylphenyl) butan-1-one; Ebastine metabolite; Carebastine; (±)-Carebastine; 1-[4-(1,1-Dimethylethyl)phenyl]-4-[4-(diphenylmethoxy)-1-piperidinyl]-1-butanone; UNII-6E862D5P8C
EINECS	Contact for details

Quality Control

Our Carebastine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity determination by HPLC, and control of specified impurities. A Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to ensure traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.