Description

trans-4-Fluorooxolan-3-Amine is a high-purity, fluorinated heterocyclic amine building block of significant interest in advanced organic synthesis. Its unique stereochemistry and fluorine substitution make it a valuable scaffold for modulating the physicochemical and biological properties of target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, particularly in central nervous system (CNS) and metabolic disease therapeutic areas.
• Agrochemical Synthesis: Used in the design of novel herbicides, fungicides, and insecticides where the fluorine atom enhances bioavailability and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Incorporated into specialty polymers and advanced materials to impart specific electronic or surface properties.
• Chemical Biology Probes: Utilized as a building block for fluorinated amino acid analogs and other probes to study biological mechanisms.
• Process Chemistry & Scale-up: Employed in route scouting and optimization for the commercial production of complex molecules.

Basic Information

Product Name	trans-4-Fluorooxolan-3-Amine
CAS No.	1627196-89-7
Molecular Formula	C4H8FNO
Molecular Weight	105.11 g/mol
Synonyms	(3R,4S)-4-Fluorotetrahydrofuran-3-amine; (3S,4R)-4-Fluorotetrahydrofuran-3-amine; trans-4-Fluorotetrahydrofuran-3-amine; 4-Fluorooxolan-3-amine; 4-Fluoro-THF-3-amine; 3-Amino-4-fluorotetrahydrofuran; Fluorinated THF amine; F-THF-amine
EINECS	Contact for details

Quality Control

Our trans-4-Fluorooxolan-3-Amine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including chiral purity verification, to ensure it meets the exacting standards required for research and development. A detailed Certificate of Analysis (COA) providing HPLC/GC purity, chiral HPLC data, and identification results (IR, NMR) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de (trans isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.