Description

Methyl 3,5-Difluoro-2-Iodobenzoate is a high-purity fluorinated and iodinated aromatic building block essential for advanced organic synthesis. Its unique structure, featuring both fluorine and iodine substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily used by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients, particularly in medicinal chemistry for creating potential drug candidates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and pesticides, where the difluoro and iodo groups can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for synthesizing specialty polymers, liquid crystals, and organic electronic materials that require specific halogenated aromatic cores.
• Cross-Coupling Reactions: The iodine atom is an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira), enabling rapid diversification of molecular scaffolds.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution on aromatic systems in medicinal and materials chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	Methyl 3,5-Difluoro-2-Iodobenzoate
CAS No.	1609079-03-9
Molecular Formula	C8H5F2IO2
Molecular Weight	298.03 g/mol
Synonyms	3,5-Difluoro-2-iodobenzoic Acid Methyl Ester; Methyl 2-Iodo-3,5-difluorobenzoate; Benzoic acid, 3,5-difluoro-2-iodo-, methyl ester; 2-Iodo-3,5-difluorobenzoic Acid Methyl Ester; Methyl 3,5-Difluoro-2-iodobenzoate; Methyl 2-Iodo-3,5-difluorobenzoate
EINECS	Contact for details

Quality Control

Our Methyl 3,5-Difluoro-2-Iodobenzoate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and development purposes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed in a dry and well-ventilated place due to potential sensitivity to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.