Description

1-(Fluoromethyl)Cyclobutane-1-Carboxylic Acid is a high-value fluorinated cyclobutane derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, featuring a carboxylic acid group and a fluoromethyl substituent on the same carbon, makes it an essential intermediate for introducing conformational rigidity and fluorine atoms into target molecules. This compound is primarily sought after by pharmaceutical and agrochemical research organizations for the development of novel active ingredients, where it is used to modulate physicochemical properties and metabolic stability.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the fluorinated cyclobutane core can enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the development of specialty polymers and advanced materials with tailored surface properties.
• Fluorine Chemistry Research: An important reagent in academic and industrial laboratories focused on exploring new C-F bond formation strategies and fluorinated scaffold libraries.
• Ligand and Catalyst Development: Utilized for constructing sophisticated chiral ligands and organocatalysts that incorporate the sterically defined cyclobutane framework.
• Proteolysis Targeting Chimera (PROTAC) Linker Component: Its rigid, bifunctional structure makes it a candidate for use in the linker region of heterobifunctional degraders.

Basic Information

Product Name	1-(Fluoromethyl)Cyclobutane-1-Carboxylic Acid
CAS No.	1553867-84-7
Molecular Formula	C7H11FO2
Molecular Weight	146.16 g/mol
Synonyms	1-(Fluoromethyl)cyclobutane-1-carboxylic acid; 1-(Fluoromethyl)cyclobutanecarboxylic acid; Cyclobutanecarboxylic acid, 1-(fluoromethyl)-; 1-Fluoromethyl-1-cyclobutanecarboxylic acid; 1553867-84-7; FCBCA; 1-Carboxy-1-(fluoromethyl)cyclobutane
EINECS	Contact for details

Quality Control

Our 1-(Fluoromethyl)Cyclobutane-1-Carboxylic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency and reliability for your research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong bases, strong oxidizing agents, and strong reducing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.