Description

2-Fluoro-4-Trifluoromethoxyacetophenone is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its unique structure, featuring both fluorine and trifluoromethoxy substituents, makes it a critical intermediate for developing novel compounds with enhanced biological activity and physical properties. This product is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Active Ingredient Development: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the fluorine atoms improve metabolic stability and bioavailability.
• Liquid Crystal & OLED Material Synthesis: Serves as a precursor for fluorinated components in electronic display materials, contributing to improved dielectric anisotropy and thermal stability.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with unique surface properties, chemical resistance, and optical characteristics.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new fluorination methodologies and constructing complex molecular architectures.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the scale-up and production of client-specific fluorinated target molecules under cGMP conditions where required.

Basic Information

Product Name	2-Fluoro-4-Trifluoromethoxyacetophenone
CAS No.	1532864-35-9
Molecular Formula	C9H6F4O2
Molecular Weight	222.14 g/mol
Synonyms	1-(2-Fluoro-4-(trifluoromethoxy)phenyl)ethan-1-one; 2'-Fluoro-4'-(trifluoromethoxy)acetophenone; 2-Fluoro-4-trifluoromethoxyacetophenone; 2-Fluoro-α,α,α-trifluoro-p-methoxyacetophenone; 4-Trifluoromethoxy-2-fluoroacetophenone; Ethanone, 1-[2-fluoro-4-(trifluoromethoxy)phenyl]-; F-TFMOC-AP
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-Trifluoromethoxyacetophenone is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and impurity profiles as determined by validated methods including HPLC, GC, NMR, and MS.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.