Description

3-Amino-2-(Trifluoromethyl)Propan-1-Ol is a versatile chiral building block featuring both amino and hydroxyl functional groups on a trifluoromethylated carbon backbone. This unique structure makes it a critical intermediate for synthesizing high-value, biologically active molecules, particularly in pharmaceutical and agrochemical research. It is essential for medicinal chemists and process development scientists working on novel drug candidates, such as protease inhibitors and other small-molecule therapeutics. The compound's defined stereochemistry and reactive sites enable precise modifications to optimize pharmacokinetic properties and target binding affinity.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the development of active pharmaceutical ingredients (APIs), especially protease inhibitors and other enzyme-targeted therapies.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Peptidomimetics Research: Used to construct non-natural amino acid analogs for studying protein-protein interactions and developing peptide-based drugs.
• Fluorine Chemistry: A valuable substrate for exploring new fluorination reactions and synthesizing complex organofluorine compounds.
• Material Science: Potential monomer or modifier for specialty polymers and coatings, imparting unique surface properties.

Basic Information

Product Name	3-Amino-2-(Trifluoromethyl)Propan-1-Ol
CAS No.	1529181-01-8
Molecular Formula	C4H8F3NO
Molecular Weight	143.11 g/mol
Synonyms	2-(Trifluoromethyl)-3-aminopropan-1-ol; 3-Amino-2-(trifluoromethyl)-1-propanol; 1-Propanol, 3-amino-2-(trifluoromethyl)-; (R/S)-3-Amino-2-(trifluoromethyl)propan-1-ol; 3-Amino-2-trifluoromethylpropanol; β-Amino-β-trifluoromethylpropanol; Amino-trifluoromethyl-propanol; TFMPA
EINECS	Contact for details

Quality Control

Our 3-Amino-2-(Trifluoromethyl)Propan-1-Ol is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity assessment, to ensure it meets the stringent requirements for advanced synthetic applications. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment, documenting identity, purity, and impurity profiles. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.