Description

2-Bromo-3,4-Difluorobenzonitrile is a high-purity, multi-functional aromatic building block featuring bromine, fluorine, and nitrile substituents. This compound matters for its role as a critical intermediate in modern synthetic chemistry, enabling the precise construction of complex molecules. Pharmaceutical, agrochemical, and advanced materials researchers need it for developing active ingredients, functional polymers, and novel electronic materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the bioactivity of the difluorobenzene core.
• Liquid Crystal & OLED Materials: Serves as a precursor for electron-transport materials and emissive layer components in organic light-emitting diodes (OLEDs) and display technologies.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig palladium-catalyzed cross-coupling reactions.
• Functional Polymer Monomer: Used to incorporate fluorine and nitrile functionality into high-performance polymers for enhanced chemical resistance and thermal stability.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D in medicinal chemistry, materials science, and synthetic methodology.

Basic Information

Product Name	2-Bromo-3,4-Difluorobenzonitrile
CAS No.	1517611-20-9
Molecular Formula	C7H2BrF2N
Molecular Weight	218.00 g/mol
Synonyms	3,4-Difluoro-2-bromobenzonitrile; 2-Bromo-3,4-difluorobenzene carbonitrile; 2-Bromo-3,4-difluorophenyl cyanide; Benzonitrile, 2-bromo-3,4-difluoro-; 1517611-20-9; 2-Br-3,4-F2-C6H2-CN
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3,4-Difluorobenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive applications like pharmaceutical R&D. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.