Description

2-Bromo-3,6-Difluorobenzonitrile is a high-purity, multi-functional halogenated aromatic nitrile building block essential for advanced organic synthesis. Its molecular structure, featuring bromine and fluorine substituents on a benzonitrile core, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the development of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the difluoro and bromo groups contribute to bioactivity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis, enabling more efficient synthetic routes.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers where halogenated aromatic units fine-tune material properties like charge transport and thermal stability.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions, allowing for the rapid diversification of chemical space in drug discovery libraries.

Basic Information

Product Name	2-Bromo-3,6-Difluorobenzonitrile
CAS No.	1502090-29-0
Molecular Formula	C7H2BrF2N
Molecular Weight	218.00 g/mol
Synonyms	2-Bromo-3,6-difluorobenzonitrile; 3,6-Difluoro-2-bromobenzonitrile; Benzonitrile, 2-bromo-3,6-difluoro-; 2-Bromo-3,6-difluorophenyl cyanide
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-3,6-Difluorobenzonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles as determined by advanced chromatographic and spectroscopic methods. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.