Description

2-Bromo-6-Fluoro-5-Methylbenzoitrile is a high-purity, multi-functional halogenated aromatic nitrile building block. This compound is valued for its unique substitution pattern, which makes it a critical intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging its halogen and nitrile functionalities.
• Material Science Research: Serves as a precursor for the development of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile scaffold or labeling agent in probe and linker molecule synthesis for target identification studies.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex biaryl structures.
• Nitrile Transformation Chemistry: The cyano group can be converted into various other functional groups such as amides, carboxylic acids, or tetrazoles, expanding its utility in medicinal chemistry.

Basic Information

Product Name	2-Bromo-6-Fluoro-5-Methylbenzoitrile
CAS No.	1501163-33-2
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	2-Bromo-6-fluoro-5-methylbenzonitrile; 5-Methyl-2-bromo-6-fluorobenzonitrile; Benzonitrile, 2-bromo-6-fluoro-5-methyl-; 1501163-33-2; 2-Bromo-6-fluoro-5-methyl-benzonitrile; 2-Bromo-6-fluoro-5-methyl benzonitrile; 2-Bromo-6-fluoro-5-methyl-benznitrile
EINECS	Contact for details

Quality Control

Our 2-Bromo-6-Fluoro-5-Methylbenzoitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.