Description

Glycine, n-(2,2-Difluoroethyl)-, 1,1-Dimethylethyl Ester is a specialized, high-purity amino acid derivative featuring a difluoroethyl side chain protected by a tert-butyl ester group. This compound matters as a critical pharmaceutical intermediate and building block for the synthesis of complex molecules, offering chemists a versatile handle for introducing fluorinated motifs. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated amino acid analogs.
• Agrochemical Research: Used in the development of advanced herbicides, pesticides, and plant growth regulators that incorporate fluorine for enhanced stability and bioactivity.
• Peptide Chemistry: Serves as a protected, fluorinated glycine derivative for the solid-phase or solution-phase synthesis of modified peptides with altered physicochemical properties.
• Medicinal Chemistry & Drug Discovery: Employed in lead optimization and structure-activity relationship (SAR) studies to explore the effects of fluorine substitution on drug metabolism and potency.
• Chemical Biology Probes: Utilized in the creation of labeled compounds and probes for studying biological mechanisms and enzyme interactions.
• Fine Chemical Synthesis: Acts as a versatile synthon for preparing more complex fluoroorganic compounds used in various high-value chemical applications.

Basic Information

Product Name	Glycine, n-(2,2-Difluoroethyl)-, 1,1-Dimethylethyl Ester
CAS No.	1488365-02-1
Molecular Formula	C9H17F2NO2
Molecular Weight	209.24 g/mol
Synonyms	N-(2,2-Difluoroethyl)glycine tert-Butyl Ester; tert-Butyl N-(2,2-difluoroethyl)glycinate; 2-[(2,2-Difluoroethyl)amino]acetic acid 1,1-dimethylethyl ester; N-(2,2-Difluoroethyl)glycine 1,1-Dimethylethyl Ester; Glycine, N-(2,2-difluoroethyl)-, tert-butyl ester; tert-Butyl 2-((2,2-difluoroethyl)amino)acetate
EINECS	Contact for details

Quality Control

Our Glycine, n-(2,2-Difluoroethyl)-, 1,1-Dimethylethyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.