Description

Benzonitrile, 3,5-Difluoro-4-Iodo- is a high-purity, halogenated aromatic nitrile building block of significant interest in advanced organic synthesis. Its unique structure, featuring iodine and fluorine substituents, makes it a versatile precursor for constructing complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists engaged in the discovery of new active ingredients, where it serves as a key intermediate for cross-coupling reactions and further functionalization.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in the development of fluorine-containing drugs.
• Agrochemical Research: Used in the creation of new herbicides, fungicides, and insecticides, leveraging the bioactivity often imparted by fluorine and iodine atoms.
• Material Science: Serves as a monomer or precursor for advanced polymers and liquid crystals with specific electronic or optical properties.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry: Acts as a starting material for further fluorination or derivatization studies in medicinal and synthetic chemistry.

Basic Information

Product Name	Benzonitrile, 3,5-Difluoro-4-Iodo-
CAS No.	1487337-76-7
Molecular Formula	C7H2F2IN
Molecular Weight	264.99 g/mol
Synonyms	3,5-Difluoro-4-iodobenzonitrile; 4-Iodo-3,5-difluorobenzonitrile; 3,5-Difluoro-4-iodo-benzonitrile; 2,6-Difluoro-4-cyanophenyl iodide; 4-Cyano-2,6-difluoro-1-iodobenzene; 1-Iodo-3,5-difluoro-4-cyanobenzene; 1487337-76-7
EINECS	Contact for details

Quality Control

Our Benzonitrile, 3,5-Difluoro-4-Iodo- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable and can support regulatory documentation needs for preclinical and clinical development stages.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or otherwise opaque.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residue on Ignition	<0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.