Description

4-Amino-3-Fluoro-5-Methylbenzonitrile is a high-purity, multi-functional aromatic nitrile building block. This compound is valued for its unique molecular architecture, featuring strategically positioned amino, fluoro, and methyl substituents on a benzonitrile core, which enables precise chemical modifications. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and advanced materials sectors for the synthesis of novel active pharmaceutical ingredients (APIs) and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Serves as a versatile scaffold for developing new herbicides, fungicides, and pesticides with enhanced efficacy.
• Material Science: Used in the development of advanced polymers, liquid crystals, and organic electronic materials due to its rigid, polar structure.
• Chemical Synthesis: Acts as a building block for creating more complex fluorinated and aminated aromatic compounds in custom synthesis projects.
• Dye & Pigment Industry: Employed in the research and development of novel fluorinated dyes and colorants.
• Academic & Contract Research: Essential for methodological studies and discovery chemistry in university and CRO (Contract Research Organization) laboratories.

Basic Information

Product Name	4-Amino-3-Fluoro-5-Methylbenzonitrile
CAS No.	1465326-80-0
Molecular Formula	C8H7FN2
Molecular Weight	150.16 g/mol
Synonyms	3-Fluoro-5-methyl-4-aminobenzonitrile; 4-Amino-3-fluoro-5-methylbenzenecarbonitrile; 5-Methyl-3-fluoro-4-aminobenzonitrile; Benzonitrile, 4-amino-3-fluoro-5-methyl-; 4-Cyano-2-fluoro-6-methylaniline; 2-Fluoro-6-methyl-4-cyanoaniline; 4-Amino-2-fluoro-6-methylbenzonitrile; 1465326-80-0
EINECS	Contact for details

Quality Control

Our 4-Amino-3-Fluoro-5-Methylbenzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or when opening sealed containers. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.