Description

(1-Fluorocyclobutyl)Methanamine Hydrochloride is a high-purity, fluorinated amine hydrochloride salt of significant interest in advanced organic synthesis. This compound serves as a critical building block for medicinal chemistry, enabling the introduction of the unique (1-fluorocyclobutyl)methylamine moiety into target molecules. It is primarily sought by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in areas targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides that leverage the fluorocyclobutyl group for enhanced bioactivity and stability.
• Peptide Mimetics & PROTACs: Incorporation into peptide backbones or as a linker component in Proteolysis Targeting Chimeras (PROTACs) and other bifunctional molecules.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or catalysts used in asymmetric synthesis.
• Material Science: Potential monomer or modifier for creating specialty polymers with tailored properties.
• Chemical Biology Probes: Useful for labeling and studying biological systems due to the fluorine atom's potential as an NMR or PET tracer handle.

Basic Information

Product Name	(1-Fluorocyclobutyl)Methanamine Hydrochloride
CAS No.	1462885-81-9
Molecular Formula	C5H11ClFN
Molecular Weight	139.60 g/mol
Synonyms	1-(Aminomethyl)-1-fluorocyclobutane hydrochloride; (1-Fluorocyclobutyl)methylamine hydrochloride; 1-Fluorocyclobutane-1-methanamine hydrochloride; (Aminomethyl)fluorocyclobutane hydrochloride; 1-Fluorocyclobutylmethylamine HCl; FCBMA-HCl
EINECS	Contact for details

Quality Control

Our (1-Fluorocyclobutyl)Methanamine Hydrochloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development applications. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is available with each shipment and upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.