Description

4-(1-Aminoethyl)-3-Fluorobenzonitrile Hcl is a high-purity, advanced pharmaceutical intermediate featuring a benzonitrile core substituted with a fluorinated aromatic ring and an aminoethyl side chain. This compound is valued for its role as a critical building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and oncology.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to develop new therapeutic agents.
• Agrochemical Synthesis: Serves as a building block for creating advanced herbicides and pesticides with enhanced efficacy.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for asymmetric catalysis and metal-organic frameworks.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical raw material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	4-(1-Aminoethyl)-3-Fluorobenzonitrile Hcl
CAS No.	1461706-66-0
Molecular Formula	C9H10FN2·HCl
Molecular Weight	200.65 (Free base) / 237.11 (HCl salt)
Synonyms	3-Fluoro-4-(1-aminoethyl)benzonitrile hydrochloride; 4-(1-Aminoethyl)-3-fluorobenzonitrile hydrochloride; 1-(4-Cyano-2-fluorophenyl)ethan-1-amine hydrochloride; 4-(Aminoethyl)-3-fluorobenzonitrile HCl; α-Methyl-3-fluoro-4-cyanobenzylamine hydrochloride; (4-Cyano-2-fluorophenyl)ethylamine hydrochloride; 2-Fluoro-4-(1-aminoethyl)benzonitrile hydrochloride
EINECS	Contact for details

Quality Control

Our 4-(1-Aminoethyl)-3-Fluorobenzonitrile Hcl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP standards for pharmaceutical intermediates, ensuring reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.