Description

3-(3,4-Difluorophenyl)Prop-2-Enenitrile is a high-purity fluorinated aromatic nitrile building block, essential for advanced organic synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its difluorophenyl moiety imparts desirable metabolic stability and lipophilicity. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, leveraging the fluorine atoms for enhanced bioactivity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated aromatic groups into polymer backbones to alter thermal stability, chemical resistance, and surface properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D exploring new fluorinated compounds and reaction methodologies.

Basic Information

Product Name	3-(3,4-Difluorophenyl)Prop-2-Enenitrile
CAS No.	1459719-83-5
Molecular Formula	C9H5F2N
Molecular Weight	165.14 g/mol
Synonyms	3-(3,4-Difluorophenyl)acrylonitrile; (E)-3-(3,4-Difluorophenyl)acrylonitrile; 3,4-Difluorocinnamomitrile; 2-Propenenitrile, 3-(3,4-difluorophenyl)-; (3,4-Difluorophenyl)ethylene carbonitrile; 3-(3,4-Difluorophenyl)-2-propenenitrile; Cinnamomitrile, 3,4-difluoro-
EINECS	Contact for details

Quality Control

Our 3-(3,4-Difluorophenyl)Prop-2-Enenitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.