Description

(1S,3S)-3-Fluoro-3-Methylcyclobutanecarboxylic Acid CAS NO 1455037-45-2 is a high-purity, chiral fluorinated cyclobutane derivative of significant interest in advanced organic synthesis. This compound serves as a critical, structurally constrained building block for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and specialty chemical sectors for creating molecules with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, where the fluorinated cyclobutane moiety can improve potency and environmental profile.
• Ligand & Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis, enabling the production of enantiomerically pure compounds.
• Material Science Precursor: Acts as a monomer or functional additive in the synthesis of advanced polymers and specialty materials with unique optical or electronic properties.
• Chemical Biology Probe: Utilized as a tagged molecular fragment or a stable isotopologue precursor in proteomics and metabolomics research to study biological pathways.

Basic Information

Product Name	(1S,3S)-3-Fluoro-3-Methylcyclobutanecarboxylic Acid
CAS No.	1455037-45-2
Molecular Formula	C7H11FO2
Molecular Weight	146.16 g/mol
Synonyms	(1S,3S)-3-Fluoro-3-methylcyclobutane-1-carboxylic acid; (1S,3S)-3-Fluoro-3-methyl-1-cyclobutanecarboxylic acid; 3-Fluoro-3-methylcyclobutanecarboxylic acid (cis-); cis-3-Fluoro-3-methylcyclobutanecarboxylic acid; (1S,3S)-rel-3-Fluoro-3-methylcyclobutanecarboxylic Acid; Fluoromethylcyclobutanecarboxylic Acid Isomer
EINECS	Contact for details

Quality Control

Our (1S,3S)-3-Fluoro-3-Methylcyclobutanecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and GC/MS, to ensure identity, purity, and enantiomeric excess meet the highest standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.