Description

2-Fluoro-5-(Trifluoromethyl)Phenyl Triflate, also known as 4-Fluoro-3-{[(Trifluoromethyl)Sulphonyl]Oxy}Benzotrifluoride, is a highly versatile and reactive aryl triflate intermediate prized for its role in advanced organic synthesis. Its value lies in its ability to act as a superior leaving group in cross-coupling reactions, enabling the efficient construction of complex fluorinated aromatic scaffolds. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic rings for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the introduction of fluorine atoms is critical for efficacy and environmental profile.
• Cross-Coupling Reactions: Serves as an excellent electrophile in palladium-catalyzed reactions such as Suzuki, Stille, and Negishi couplings to form biaryl and other complex structures.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands and organometallic catalysts for asymmetric synthesis and polymerization processes.
• Material Science Research: A precursor for synthesizing fluorinated polymers, liquid crystals, and organic electronic materials with unique optical and electronic properties.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated probes and tags for imaging and diagnostic applications.

Basic Information

Item	Details
Product Name	2-Fluoro-5-(Trifluoromethyl)Phenyl Triflate
CAS No.	1446016-79-0
Molecular Formula	C8H3F7O3S
Molecular Weight	312.16 g/mol
Synonyms	4-Fluoro-3-{[(Trifluoromethyl)Sulphonyl]Oxy}Benzotrifluoride; 2-Fluoro-5-(trifluoromethyl)phenyl trifluoromethanesulfonate; 2-Fluoro-α,α,α-trifluoro-p-tolyl Triflate; 5-(Trifluoromethyl)-2-fluorophenyl Triflate; (2-Fluoro-5-(trifluoromethyl)phenyl) trifluoromethanesulfonate; 4-Fluoro-3-(triflyloxy)benzotrifluoride; 2-Fluoro-5-trifluoromethylphenyl Triflate
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-5-(Trifluoromethyl)Phenyl Triflate is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical synthetic applications. Our products undergo rigorous analytical testing, including HPLC, NMR, and GC-MS, to verify identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its nature as a strong acid/organic solvent and highly volatile compound, ensure containers are kept tightly sealed and away from heat, sparks, and open flames. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.