Description

5-Bromo-4-Fluoro-2-Hydroxybenzonitrile is a high-value, multi-functional aromatic nitrile derivative. This compound serves as a critical synthetic intermediate, prized for its unique halogenated and hydroxylated benzonitrile structure which enables diverse chemical transformations. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly in the synthesis of active pharmaceutical ingredients (APIs) and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging its halogenated aromatic core.
• Material Science Research: Serves as a precursor for functionalized polymers and liquid crystals due to its polar nitrile and hydroxyl groups.
• Organic Synthesis Reagent: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution due to the reactive bromo and fluoro substituents.
• Chemical Biology Probe Development: Utilized as a scaffold for creating fluorescent tags or enzyme inhibitors in biochemical research.

Basic Information

Product Name	5-Bromo-4-Fluoro-2-Hydroxybenzonitrile
CAS No.	1445967-94-1
Molecular Formula	C7H3BrFNO
Molecular Weight	216.01 g/mol
Synonyms	2-Hydroxy-5-bromo-4-fluorobenzonitrile; 4-Fluoro-5-bromo-2-hydroxybenzonitrile; 5-Bromo-4-fluoro-2-hydroxybenzonitrile; 2-Cyano-4-fluoro-5-bromophenol; Benzonitrile, 5-bromo-4-fluoro-2-hydroxy-; 1445967-94-1
EINECS	Contact for details

Quality Control

Our 5-Bromo-4-Fluoro-2-Hydroxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents and strong bases. The product is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.