Description

(R)-3-(Fluoromethyl)Pyrrolidine Hydrochloride is a high-value chiral building block and intermediate in organic synthesis. This compound is critical for the development of novel active pharmaceutical ingredients (APIs), particularly in the fields of neurology and metabolic disease research. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and fine chemical manufacturers seeking to incorporate a fluorinated pyrrolidine moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of potential drug candidates targeting central nervous system (CNS) disorders.
• Agrochemical Research: Building block for developing novel fluorinated pesticides and herbicides with enhanced biological activity and stability.
• Ligand Synthesis: Precursor for creating chiral ligands and catalysts used in asymmetric synthesis.
• PET Tracer Development: Potential intermediate in the synthesis of fluorine-18 labeled compounds for Positron Emission Tomography (PET) imaging.
• Peptidomimetics: Incorporation into peptide analogs to modulate bioavailability and metabolic stability.
• Chemical Biology Probes: Used in the design of molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	(R)-3-(Fluoromethyl)Pyrrolidine Hydrochloride
CAS No.	1443983-87-6
Molecular Formula	C5H11FN • HCl
Molecular Weight	139.60 (Free base) / 176.06 (HCl salt)
Synonyms	(R)-3-(Fluoromethyl)pyrrolidine HCl; (R)-3-Fluoromethylpyrrolidine hydrochloride; (3R)-3-(Fluoromethyl)pyrrolidine hydrochloride; Pyrrolidine, 3-(fluoromethyl)-, (3R)-, hydrochloride; (R)-3-Fluoromethyl-pyrrolidine HCl salt; (R)-3-(FM)Pyrrolidine HCl; (R)-N-Boc-3-(fluoromethyl)pyrrolidine deprotected salt
EINECS	Contact for details

Quality Control

Our (R)-3-(Fluoromethyl)Pyrrolidine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere or in a controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.