Description

5-(2,5-Difluorophenyl)-3,4-Dihydro-2H-Pyrrole is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. This compound matters because its unique difluorophenyl-substituted pyrrolidine core provides a critical structural motif for modulating the physicochemical and pharmacokinetic properties of target molecules. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and oncology targets.
• Agrochemical Research: Used to construct advanced scaffolds for new herbicides, fungicides, and insecticides, leveraging fluorine's effects on bioactivity.
• Material Science Building Block: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Medicinal Chemistry SAR Studies: Serves as a core structure for structure-activity relationship (SAR) exploration to optimize potency and selectivity.
• Fluorine Chemistry Research: A valuable substrate for studying fluorinated aromatic systems in heterocyclic chemistry.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and custom synthesis projects.

Basic Information

Product Name	5-(2,5-Difluorophenyl)-3,4-Dihydro-2H-Pyrrole
CAS No.	1443623-92-4
Molecular Formula	C10H9F2N
Molecular Weight	181.18 g/mol
Synonyms	5-(2,5-Difluorophenyl)-2,3-dihydro-1H-pyrrole; 2,5-Difluorophenylpyrrolidine; 1-(2,5-Difluorophenyl)pyrrolidine; 5-(2,5-Difluorophenyl)pyrrolidine; 2,3-Dihydro-5-(2,5-difluorophenyl)-1H-pyrrole; 1443623-92-4; 5-(2,5-Difluorophenyl)-3,4-dihydro-2H-pyrrole
EINECS	Contact for details

Quality Control

Our 5-(2,5-Difluorophenyl)-3,4-Dihydro-2H-Pyrrole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our commitment to quality supports your R&D and scale-up processes with reliable, high-purity material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.