Description

(2R,6R)-2-Methyl-6-(Trifluoromethyl)Morpholine Hydrochloride is a high-purity chiral building block and intermediate of significant interest in advanced pharmaceutical synthesis. Its value lies in its defined stereochemistry and the trifluoromethyl group, which are critical for modulating the biological activity, metabolic stability, and lipophilicity of drug candidates. This compound is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the construction of complex molecular architectures for potential drug candidates.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Asymmetric Synthesis: Employed in catalytic and stoichiometric asymmetric reactions due to its rigid morpholine backbone.
• Fluorine Chemistry Applications: The trifluoromethyl group makes it valuable for introducing fluorine into molecules to enhance their drug-like properties.
• Pre-clinical and Clinical Trial Material Production: Supplied for the synthesis of compounds required for toxicology studies and clinical batches.

Basic Information

Product Name	(2R,6R)-2-Methyl-6-(Trifluoromethyl)Morpholine Hydrochloride
CAS No.	1432731-32-2
Molecular Formula	C6H11F3NO • HCl
Molecular Weight	209.62 g/mol (Free base: 169.16 g/mol)
Synonyms	(2R,6R)-2-Methyl-6-(trifluoromethyl)morpholine HCl; (2R,6R)-2-Methyl-6-(trifluoromethyl)morpholine hydrochloride; (2R,6R)-2-Methyl-6-(trifluoromethyl)-tetrahydro-1,4-oxazine hydrochloride; (2R,6R)-2-Methyl-6-(trifluoromethyl)morpholine monohydrochloride; (2R,6R)-2-Methyl-6-(trifluoromethyl)-1,4-oxazinane hydrochloride; (R,R)-2-Methyl-6-(trifluoromethyl)morpholine HCl; CAS 1432731-32-2
EINECS	Contact for details

Quality Control

Our (2R,6R)-2-Methyl-6-(Trifluoromethyl)Morpholine Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines and can provide material for GMP-regulated applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.