Description

3-Bromo-2-Fluoro-6-Methoxybenzonitrile is a high-purity, multi-functional aromatic building block of significant interest in advanced organic synthesis. Its core value proposition lies in its unique substitution pattern, which provides multiple orthogonal reactive sites for constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing substituted benzonitrile or fluorinated aromatic motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of halogenated and methoxylated aromatic systems.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl structures.
• Nucleophilic Aromatic Substitution: The fluorine atom at the ortho position to the nitrile is activated for substitution, allowing for further functionalization.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological systems.

Basic Information

Product Name	3-Bromo-2-Fluoro-6-Methoxybenzonitrile
CAS No.	1428478-66-3
Molecular Formula	C8H5BrFNO
Molecular Weight	230.04 g/mol
Synonyms	2-Fluoro-6-methoxy-3-bromobenzonitrile; 3-Bromo-2-fluoro-6-methoxybenzonitrile; Benzonitrile, 3-bromo-2-fluoro-6-methoxy-; 2-Fluoro-3-bromo-6-methoxybenzonitrile; 6-Methoxy-3-bromo-2-fluorobenzonitrile
EINECS	Contact for details

Quality Control

Our 3-Bromo-2-Fluoro-6-Methoxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.