Description

4-Bromo-2-Chloro-3-Fluorobenzonirile is a high-purity, multi-halogenated benzonitrile derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug research.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, leveraging its halogenated aromatic structure.
• Liquid Crystal & OLED Materials: Serves as a precursor for electron-deficient aromatic cores in electronic materials for displays and lighting.
• Organic Ligand Synthesis: Employed in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions due to the bromo and chloro substituents.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry, material science, and general synthetic chemistry explorations in R&D laboratories.

Basic Information

Product Name	4-Bromo-2-Chloro-3-Fluorobenzonirile
CAS No.	1427439-32-4
Molecular Formula	C7H2BrClFN
Molecular Weight	234.45 g/mol
Synonyms	2-Chloro-4-bromo-3-fluorobenzonitrile; 3-Fluoro-4-bromo-2-chlorobenzonitrile; 4-Bromo-2-chloro-3-fluorobenzene carbonitrile; Benzonitrile, 4-bromo-2-chloro-3-fluoro-; 1427439-32-4; 4-Br-2-Cl-3-F-Bn
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Chloro-3-Fluorobenzonirile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance in regulated applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.