Description

Benzonitrile, 4-Bromo-2-Fluoro-6-Methyl- CAS NO 1427438-75-2 is a high-purity, multi-substituted aromatic nitrile building block of significant interest in advanced organic synthesis. Its unique halogenated structure makes it a valuable precursor for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for researchers and process chemists developing active pharmaceutical ingredients (APIs), liquid crystal materials, and functionalized ligands for catalysis.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides and fungicides with specific modes of action.
• Liquid Crystal & OLED Materials: Serves as a building block for creating fluorinated and brominated aromatic cores essential for electronic materials with tailored electro-optical properties.
• Catalyst Ligand Preparation: Employed in the synthesis of specialized phosphine or nitrogen-based ligands for transition metal catalysis.
• Chemical Research & Development: A versatile reagent for exploring new cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and introducing functional groups into complex molecular architectures.
• Advanced Polymer Modification: Can be used to incorporate nitrile and halogen functionalities into polymer backbones for enhanced thermal or chemical resistance.

Basic Information

Product Name	Benzonitrile, 4-Bromo-2-Fluoro-6-Methyl-
CAS No.	1427438-75-2
Molecular Formula	C8H5BrFN
Molecular Weight	214.04 g/mol
Synonyms	4-Bromo-2-fluoro-6-methylbenzonitrile; 2-Fluoro-4-bromo-6-methylbenzonitrile; 6-Methyl-4-bromo-2-fluorobenzonitrile; 4-Bromo-2-fluoro-6-methyl-benzonitrile; Benzonitrile, 4-bromo-2-fluoro-6-methyl-; 4-Bromo-2-fluoro-6-methylbenzenecarbonitrile; (4-Bromo-2-fluoro-6-methylphenyl)cyanide
EINECS	Contact for details

Quality Control

Our Benzonitrile, 4-Bromo-2-Fluoro-6-Methyl- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.