Description

(S)-2-Trifluoromethyl-Piperazine Dihydrochloride CAS NO 1427203-58-4 is a high-purity, chiral piperazine derivative of significant importance in modern pharmaceutical research and development. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) for constructing novel drug candidates, particularly leveraging the unique properties of the trifluoromethyl group. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) engaged in the synthesis of active pharmaceutical ingredients (APIs) for central nervous system (CNS) drugs, oncology therapeutics, and other specialized medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially for CNS and oncology targets.
• Medicinal Chemistry Research: Used in drug discovery programs to explore structure-activity relationships (SAR) and improve metabolic stability and bioavailability.
• Asymmetric Synthesis: Employed as a chiral auxiliary or scaffold in the preparation of enantiomerically pure compounds.
• Ligand and Catalyst Development: Serves as a precursor for creating novel ligands and catalysts used in asymmetric catalysis.
• Agrochemical Research: Potential intermediate in the development of new, high-performance agrochemicals.
• Material Science: Investigated for the synthesis of specialized polymers and advanced materials with unique fluorinated properties.

Basic Information

Product Name	(S)-2-Trifluoromethyl-Piperazine Dihydrochloride
CAS No.	1427203-58-4
Molecular Formula	C5H10F3N2 • 2HCl
Molecular Weight	255.07 g/mol
Synonyms	(S)-2-(Trifluoromethyl)piperazine dihydrochloride; (S)-2-Trifluoromethylpiperazine dihydrochloride; (S)-2-Trifluoromethylpiperazine hydrochloride (1:2); (S)-α-(Trifluoromethyl)piperazine dihydrochloride; (S)-Piperazine, 2-(trifluoromethyl)-, dihydrochloride; (2S)-2-(Trifluoromethyl)piperazine dihydrochloride; (S)-(-)-2-Trifluoromethylpiperazine dihydrochloride
EINECS	Contact for details

Quality Control

Our (S)-2-Trifluoromethyl-Piperazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm enantiomeric excess, ensuring it meets the high standards required for pharmaceutical R&D. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Recommended long-term storage at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.