Description

4-Bromo-2-Fluoro-3-Methoxybenzonitrile is a high-purity, multi-functional aromatic nitrile building block of significant interest in advanced organic synthesis. Its value lies in the strategic positioning of bromine, fluorine, and methoxy substituents, which allow for selective cross-coupling reactions and the introduction of key pharmacophores. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science Research: Serves as a precursor for functionalized polymers, liquid crystals, and organic electronic materials due to its aromatic core and substituents.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and Buchwald-Hartwig amination reactions to construct complex biaryl systems.
• Fluorine Chemistry: The fluorine substituent is utilized to modulate lipophilicity, metabolic stability, and bioavailability in candidate molecules.
• Nitrile Functionalization: The cyano group can be hydrolyzed to carboxylic acids, reduced to amines, or used in cycloaddition reactions to form heterocycles.

Basic Information

Product Name	4-Bromo-2-Fluoro-3-Methoxybenzonitrile
CAS No.	1426073-33-7
Molecular Formula	C8H5BrFNO
Molecular Weight	230.04 g/mol
Synonyms	3-Methoxy-4-bromo-2-fluorobenzonitrile; 2-Fluoro-3-methoxy-4-bromobenzonitrile; 4-Bromo-2-fluoro-3-methoxybenzonitrile; Benzonitrile, 4-bromo-2-fluoro-3-methoxy-; 1426073-33-7; 4-Br-2-F-3-MeO-benzonitrile
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Fluoro-3-Methoxybenzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.