Description

3-Bromo-6-Fluoro-2-Methoxybenzonitrile is a high-purity, multi-functional aromatic nitrile building block designed for advanced chemical synthesis. Its value lies in the strategic positioning of bromine, fluorine, and methoxy substituents, which enable precise molecular modifications and the introduction of key pharmacophores. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel materials through cross-coupling reactions and heterocyclic synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its rigid, substituted benzene core.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to construct complex biaryl systems.
• Fluorinated Compound Libraries: Integral for medicinal chemistry programs focused on synthesizing fluorinated compound libraries to study structure-activity relationships (SAR).
• Chemical Biology Probes: Used in the development of molecular probes and tags for studying biological processes and target engagement.

Basic Information

Product Name	3-Bromo-6-Fluoro-2-Methoxybenzonitrile
CAS No.	1426073-18-8
Molecular Formula	C8H5BrFNO
Molecular Weight	230.04 g/mol
Synonyms	2-Methoxy-3-bromo-6-fluorobenzonitrile; 6-Fluoro-2-methoxy-3-bromobenzonitrile; 3-Bromo-6-fluoro-2-methoxybenzonitrile; Benzonitrile, 3-bromo-6-fluoro-2-methoxy-; 1426073-18-8; 3-Br-6-F-2-MeO-benzonitrile
EINECS	Contact for details

Quality Control

Our 3-Bromo-6-Fluoro-2-Methoxybenzonitrile is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production adheres to cGMP principles where applicable, ensuring consistency, traceability, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.