Description

4-Bromo-2-Ethoxy-5-Fluorobenzonitrile is a high-purity fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its molecular structure, featuring bromine, fluorine, and ethoxy substituents on a benzonitrile core, makes it a versatile intermediate for constructing complex molecules. This compound is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine atom enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized monomers for specialty polymers and liquid crystals.
• Chemical Biology Probes: Useful for synthesizing fluorescent tags or molecular probes for biochemical and cellular studies.

Basic Information

Product Name	4-Bromo-2-Ethoxy-5-Fluorobenzonitrile
CAS No.	1423037-19-7
Molecular Formula	C9H7BrFNO
Molecular Weight	244.06 g/mol
Synonyms	5-Fluoro-2-ethoxy-4-bromobenzonitrile; 2-Ethoxy-5-fluoro-4-bromobenzonitrile; 4-Bromo-5-fluoro-2-ethoxybenzonitrile; Benzonitrile, 4-bromo-2-ethoxy-5-fluoro-; 1423037-19-7
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Ethoxy-5-Fluorobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.