Description

(3S,4R)-3-Fluorooxan-4-Amine Hydrochloride is a high-purity chiral building block and pharmaceutical intermediate. This compound is valued for its defined stereochemistry and fluorine moiety, which are critical for modulating the biological activity and metabolic stability of target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry and process research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to introduce fluorine atoms and explore stereochemical effects on potency and selectivity.
• Process Chemistry Development: Serves as a starting material or advanced intermediate for scaling up GMP-compliant synthetic routes.
• Agrochemical Research: Potential application in the development of novel pesticides and herbicides where the fluorine-substituted tetrahydropyran scaffold can enhance activity.
• Academic Research: Employed in organic synthesis methodologies and catalysis studies for constructing fluorinated heterocycles.

Basic Information

Product Name	(3S,4R)-3-Fluorooxan-4-Amine Hydrochloride
CAS No.	1422188-16-6
Molecular Formula	C5H11ClFNO
Molecular Weight	155.60 g/mol
Synonyms	(3S,4R)-3-Fluoro-tetrahydropyran-4-amine hydrochloride; 4-Amino-3-fluoro-tetrahydropyran hydrochloride (3S,4R)-isomer; (3S,4R)-3-Fluoro-4-aminotetrahydropyran HCl; 3-Fluorooxan-4-amine hydrochloride, (3S,4R)-; (3S,4R)-3-Fluoro-4-aminoxane hydrochloride; 4-Amino-3-fluorotetrahydropyran hydrochloride, trans-; FL-THP-NH2·HCl (S,R)
EINECS	Contact for details

Quality Control

Our (3S,4R)-3-Fluorooxan-4-Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to confirm stereochemical purity and identity. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing purity, assay, and impurity profiles to ensure compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.